The Analysis Of Rbmy1 Sts Rbmi Microdeletion Gene on Azoospermic Factor (Azf) Region of The Y Chromosome in Infertile Men in Palembang

Febriyanto, Tedy (2019) The Analysis Of Rbmy1 Sts Rbmi Microdeletion Gene on Azoospermic Factor (Azf) Region of The Y Chromosome in Infertile Men in Palembang. Atlantis Press, Advances in Health Sciences Research (AHSR), pp. 129-132.

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Abstract

Abstract−Approximately 50-80 million couples have infertility problems, and every year appeared about 2 million new infertile couples. As many as 40% of them are caused by male factors. Male infertility generally occursdue to abnormal spermatozoa. One of the causes is related to the deletion of gene onAzoospermic Factor (AZF) regionof the Y chromosome. One of the candidate genes in that region is RBMY1. This study is a descriptive study that aims to determine the molecular frequency RBMY1 gene microdeletion in AZF region of the Y chromosome uses STS RBM1 in infertile men in Palembang. The number of samples was 39 people. The analysis was done by using Polymerase Chain Reaction (PCR) and electrophoresis on 2% agarose gel. From this research, it was found that the frequency of microdeletions on the AZF region of the Y chromosome uses STS RBM1 of infertile men in Palembang was 7.7%. Further studies onmicrodeletion region of Azoospermic factor (AZF) of the Y chromosome in interfile menin Palembang, with other genes or by using criteria on only male factor, for example oligozoospermia, oligozoospermia extreme or cryptozoospermia were used as samples.

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